062 Sera of patients with bullous pemphigoid and mucous membrane pemphigoid react with a C-terminal 246 amino acid stretch of BP180
نویسندگان
چکیده
منابع مشابه
Mucous membrane pemphigoid
Introduction Identifying risk factors for leprosy reactions can preempt clinicians to initiate prompt treatment to prevent associated morbidities. Thus, a retrospective study was done to elucidate the risk factors among 44 newly diagnosed leprosy patients in Sarawak General Hospital from 1993 to 2007. Materials and methods Case folders were searched for demographic data, clinical characteristic...
متن کاملMucous membrane pemphigoid with severe esophageal stricture.
Mucous membrane pemphigoid (MMP) is a rare nosological entity. MMP consists of a clinical phenotype in which several autoimmune subepidermal bullous diseases are classified. It occurs predominantly in the mucous membranes and usually results in scarring. Esophageal involvement in MMP is rare and is generally seen in patients in whom lesions are widespread. The most common alterations are multip...
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Pemphigoid and pemphigus vulgaris (PV) are autoimmune diseases that cause potentially debilitating erosions and blistering of the skin and/or mucous membranes. In bullous pemphigoid (BP), autoantibodies target components of the basement membrane zone (BMZ), most importantly the hemidesmosomal proteins, BP180 and BP230. Research efforts have uncovered some of the complex mechanisms that cause th...
متن کاملMucous Membrane Pemphigoid with Tracheal Involvement
34-year-old African American female with history of pemphigoid presented with hemoptysis. Patient was found to have mucous membrane pemphigoid involving the oropharynx and extending to trachea, till just above main stem carina. Four other cases described mucosal pemphigoid involving the trachea. We hereby present a brief review of current consensus on management of mucous membrane pemphigoid wi...
متن کاملSerum Levels of Autoantibodies to BP180 Correlate With Disease Activity in Patients With Bullous Pemphigoid
Main Outcome Measures: Disease activity, serum levels of autoantibodies to BP180, and titers of anti– basement membrane zone autoantibodies were assayed before initiation of treatment and 4 and 8 weeks later. Reactivity to BP180 was analyzed by enzyme-linked immunosorbent assay using a recombinant form of BP180 NC16A. Titers of anti–basement membrane zone autoantibodies were assayed by indirect...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2019
ISSN: 0022-202X
DOI: 10.1016/j.jid.2019.07.065